Reagents for enantioselective acylation and related reactions
US5646287A · kind A · utility
2Cited by
0References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 17, 1995 |
| Grant date | Jul 8, 1997 |
| Priority date | — |
| Expiry date | May 17, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides a method for synthesizing chiral compounds utilizing novel catalysts which are enantioselective electrophiles via kinetic resolution. The method includes treating a racemic mixture with a reagent which is a chiral DMAP derivative, a chloroformate, a trialkylamine and a Lewis acid to preferentially form a product of one of the enantiomer pair of the mixture. The invention also provides a method for resolving racemic mixture via parallel kinetic resolution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.