Detection of inherited and somatic mutations of APC gene in colorectal cancer of humans

US5648212A · kind A · utility

Assignees

• The John Hopkins University · US
• University of Utah · US
• Japanese Foundation for Cancer Research Cancer Institute · JP
• Zeneca Limited · GB

Inventors

• Hans Albertsen · Salt Lake City, US
• Rakesh Anand · Rastatt, DE
• Mary Carlson · Salt Lake City, US
• Joanna Groden · Cincinnati, US
• Philip John Hedge · Grafton, GB
• Geoff Joslyn · Salt Lake City, US
• Kenneth W. Kinzler · Baltimore, US
• Alexander Fred Markham · Crewe, US
• Yusuke Nakamura · Bunkyo, JP
• Andrew Thliveris · Salt Lake City, US
• Bert Vogelstein · Baltimore, US
• Raymond L. White · Salt Lake City, US

Key dates

• Filing date: Aug 12, 1994
• Grant date: Jul 15, 1997
• Expiry date: Aug 12, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/828
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Methods are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. APC is a tumor suppressor.