Methods of treating inflammation using selection binding compounds

US5648344A · kind A · utility

Assignee

• Glycomed Incorporated · US

Inventors

• Brian K. Brandley · Alameda, US
• Michael Tiemeyer · Oakland, US
• Stuart J. Swiedler · Oakland, US
• Margaret Moreland · Berkeley, US
• Hans Schweingruber · Mountain View, US
• Narasinga Rao · Alameda, US

Key dates

• Filing date: Jul 30, 1992
• Grant date: Jul 15, 1997
• Expiry date: Jul 30, 2012

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Ligands that bind to human selectin receptors are disclosed. The ligands are formulated with excipient carriers to form compositions which are administered to treated condition such as inflammation. The ligands have the structural formula III ##STR1## or molecules which have hydrogen bond donor groups equivalent to the circled groups with respect to their ability to form hydrogen bonds with a selectin under physiological conditions.