Fibrinogen receptor antagonists

US5648368A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Melissa Egbertson · Ambler, US
• Laura Vassallo · Springfield, US
• George D. Hartman · Lansdale, US
• Wasyl Halczenko · Lansdale, US
• David B. Whitman · Harleysville, US
• James J. Perkins · Nazareth, US
• Amy E. Krause · Blue Bell, US
• Nathan Ihle · Mercer Island, US
• David A. Claremon · Audubon, US
• William F. Hoffman · Lansdale, US
• Mark E. Duggan · Wellesley, US

Key dates

• Filing date: Jun 1, 1995
• Grant date: Jul 15, 1997
• Expiry date: Jun 1, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel fibrinogen receptor antagonists of the formula: EQU X--Y--Z--Aryl--A--B are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.