Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof

US5648381A · kind A · utility

Assignee

• Innothera · FR

Inventors

• Michel P. Cugnon de Sevricourt · Moult, FR
• Catherine Dacquet · Paris, FR
• Michel Finet · Fresnes, FR
• Florence J. Le Marquer · Paris, FR
• Max Robba · Paris, FR
• Norbert O. Tembo · Cergy, FR
• Sylvie Yannic-Arnoult · Épinay-sur-Orge, FR
• Jean-Luc Torregrosa · Saint-Denis, FR

Key dates

• Filing date: Mar 24, 1994
• Grant date: Jul 15, 1997
• Expiry date: Mar 24, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of use in therapy and having the formula: ##STR1## in which R.sub.2 and R.sub.3 independently denote H, C.sub.1 -C.sub.4 alkoxy or OH and (A, B)=(oxygen, oxygen) in which case one out of R and R.sub.1 denotes OH, halogen, secondary amino or tertiary amine and the other denotes NHCOR.sub.4, NHNHCOR.sub.5 or NHNHCOCONH.sub.2, or R and R.sub.1 together form .dbd.N--NH--CO--R'.sub.5, .dbd.N--NH--CO--CO--NH.sub.2, (.dbd.N--NH--R.sub.6, .dbd.N--R.sub.7, .dbd.N--O--CO--R.sub.8 or .dbd.C(CH.sub.3)--NH--NH--CO--R.sub.9 ; or (A, B) .dbd.(N--NH--CX--NHR.sub.10, oxygen) in which case R and R.sub.1 together form .dbd.N--OH.