One vial method for labeling antibodies with Technetium-99m
US5648471A · kind A · utility
63Cited by
14References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 7, 1991 |
| Grant date | Jul 15, 1997 |
| Priority date | — |
| Expiry date | Mar 7, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A one vial method for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is disclosed. The method comprises contacting an antibody mixture comprised of a sulfhydryl containing antibody or antibody fragment and a reducing agent with technetium-99m in an oxidized state. In a preferred embodiment, the antibody mixture further contains a water soluble ligand. A one vial kit for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.