Patent · US Expired

2'-deoxy-2', 2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates

US5648473A · kind A · utility

6Cited by
7References
9Claims
0Family size

Assignee

Inventor

Key dates

Filing dateMay 30, 1995
Grant dateJul 15, 1997
Priority date
Expiry dateMay 30, 2015

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07H19/04
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

A stereoselective glycosylation process for preparing beta-anomer enriched 2'-deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides which involves reacting an alpha-anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-deoxy-2-fluorocarbohydrate with at least a molar equivalent of a pyrimidine nucleobase derivative in a low freezing inert solvent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.