Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
US5648498A · kind A · utility
Assignee
Inventors
- Endre Palosi
- Dezso Korbonits
- Erzsebet Molnar nee Bako
- Ida Szvoboda nee Kanzel
- Gergely Heja
- Pal Kiss
- Csaba Gonczi
- Ferenc Sperber
- Csaba Huszar
- Gyorgy Mihalovics
- Attila Nemeth
- Mihaly Sut
- Karol Gyure
- Istvan Bone
- Ferenc Morasz
- Laszlo Ledniczky
- Erzsebet Szabo nee Kardos
- Peter Gyri
- Erzsebet Szalay
- Karoly Ban
- Ildiko Buttkai
- Arpad Kvari
- Sandor Garaczy
Key dates
| Filing date | Jun 27, 1994 |
| Grant date | Jul 15, 1997 |
| Priority date | — |
| Expiry date | Jun 27, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is described for the preparation of 4-Methyl-5-(2-Chloroalkyl)-thiazole wherein the alkyl ranges from C.sub.2 -C.sub.5, by providing the steps of either a) converting the 3-thiocyanato-5-chloro-2-alkanone into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole by gaseous hydrochloric acid in an organic solvent and hydrogenating the compound in the presence of a metal catalyst in an organic solvent, or b) reacting 3-thiocyanato-5-choro-2-alkanone with aqueous mineral acid and treating the thiazole obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole in an organic solvent in presence of a metal catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.