Column agglutination assay and device using biphasic centrifugation
US5650068A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 16, 1996 |
| Grant date | Jul 22, 1997 |
| Priority date | — |
| Expiry date | Apr 16, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/255
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a method and device for detecting the presence of binding ligands, especially blood group antigens or antibodies thereto, which utilize a matrix of substantially noncompressable microparticles, which matrix provides superior performance in allowing movement of nonagglutinated reactants, especially red blood cells, while constraining, preferably in a so-called "band formation" agglutinated reactants, especially red blood cells. The device of the invention further comprises a chamber the transverse cross-sectional shape thereof being an ellipse, or preferably a flattened ellipse with two sides parallel to the longitudinal axis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.