Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
US5650234A · kind A · utility
209Cited by
5References
21Claims
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Key dates
| Filing date | Sep 9, 1994 |
| Grant date | Jul 22, 1997 |
| Priority date | — |
| Expiry date | Sep 9, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31663
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Several poly(ethylene glycol) mixed carbonates and their preparation are closed. These carbonates are synthesized by conversion of polyethylene glycol first to the chloroformate then by reaction with the hydroxyl group of N-hydroxybenzotriazole or 2-hydroxypyrimidine or N-hydroxy-2-pyrrolidinone. These mixed carbonate analogs smoothly react with amino groups in aminoglycans and protein and amino containing surfaces to form stable, hydrolysis resistant carbamate linkages.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.