Process for the preparation of an oxoetiocholenic acid
US5650526A · kind A · utility
2Cited by
3References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 28, 1995 |
| Grant date | Jul 22, 1997 |
| Priority date | — |
| Expiry date | Aug 28, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0094
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention is drawn to a process for the preparation of oxoetiocholenic acid of the formula I ##STR1## by reacting a compound of the formula II ##STR2## with a halonitrile in the presence of a base followed by formation of a 3-ketone group. The intermediate formed is reacted with an acid of the formula HX in an anhydrous medium followed by dehydrohalogenation of the resulting compound in the presence of a base. The intermediate produced then undergoes alkaline hydrolysis followed by a conventional acid treatment to obtain the compound of formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.