Pharmaceutically acceptable fixed-dried human blood platelets

US5651966A · kind A · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Marjorie S. Read · Durham, US
• Robert L. Reddick · Durham, US
• Arthur P. Bode · Greenville, US

Key dates

• Filing date: Nov 28, 1994
• Grant date: Jul 29, 1997
• Expiry date: Nov 28, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2400/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.