2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

US5652254A · kind A · utility

Assignee

• Sanofi S.A. · CH

Inventors

• Richard P. Dunlap · Penfield, US
• Dennis J. Hlasta · Doylestown, US
• Ranjit C. Desai · Colonie, US
• Lee H. Latimer · Oakland, US
• Chakrapani Subramanyam · South Glastonbury, US
• John J. Court · Littleton, US
• Malcolm R. Bell · East Greenbush, US
• Virendra Kumar · Paoli, US

Key dates

• Filing date: Aug 28, 1996
• Grant date: Jul 29, 1997
• Expiry date: Aug 28, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.