Therapeutic agents

US5652271A · kind A · utility

Assignee

• Knoll, Inc. · DE

Inventors

• Paul J. Harris · San Diego, US
• David John Heal · Nottingham, GB

Key dates

• Filing date: Dec 22, 1995
• Grant date: Jul 29, 1997
• Expiry date: Dec 22, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which m is 0, 1 or 2; n is 2, 3, 4 or 5; X is carbonyl or a group of formula II ##STR2## in which R.sub.5 is H or alkyl; Y is an alkylene chain optionally substituted by one or more alkyl groups; Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups; R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and R.sub.1 and R.sub.2, which are the same or different, are H, alkyl, or arylalkyl, provided that when R.sub.1 is benzyl, R.sub.2 is H or methyl; have utility in the treatment of depression, anxiety, Parkinson's disease, obesity, cognitive disorders, seizures, neurological disorders such as epilepsy, and as neuroprotective agents to protect against conditions such as stroke.