Methods for detection of nephropathy-related immunoglobulin G using monoclonal antibodies specific for nephropathy-related immunoglobulin G
US5654158A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 7, 1995 |
| Grant date | Aug 5, 1997 |
| Priority date | — |
| Expiry date | Aug 7, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/347
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A novel immunoglobulin-like glycoprotein is described which has been found to occur in high concentrations in the urine of patients with glomerulosclerosis of end-stage renal disease. This nephropathy-related protein is also found at a high frequency in the urine of patients with a high risk of developing kidney disease, as well as in the urine of kidney transplant recipients who are experiencing early signs of organ failure or rejection. Although this glycoprotein has several antigenic epitopes which are identical to those on normal human IgG molecules, two monoclonal antibodies have been developed which bind epitopes which are unique to this nephropathy-related immunoglobulin-like molecule. Immunometric assays have been developed which permit this nephropathy-related protein to serve as an early and specific marker for kidney-related diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.