Neuroblastoma-associated regulator gene
US5654188A · kind A · utility
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Key dates
| Filing date | Jun 23, 1994 |
| Grant date | Aug 5, 1997 |
| Priority date | — |
| Expiry date | Jun 23, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/828
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described is a gene situated in the region of the neuroblastoma consensus deletion 1p36.2-p36.1 and which codes for a helix-loop-helix protein with the designation HEIR-1. The gene is affected significantly by allelic tumor deletions in neuroblastomas and correlates inversely both N-myc overexpression in tumors and with N-myc expression in normal development. The cDNA and antibodies coding for HEIR-1 are used for the diagnosis of pathological conditions associated with aberration in the region of the neuroblastoma consensus deletion.
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