Composition for tissues to sustain viability and biological functions in surgery and storage
US5654266A · kind A · utility
Inventors
Key dates
| Filing date | Mar 28, 1994 |
| Grant date | Aug 5, 1997 |
| Priority date | — |
| Expiry date | Mar 28, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N1/126
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition composing ketone bodies and/or precursors thereof and an aqueous phosphate-buffered balanced salt solution with citrate, HPO.sub.4.sup.-2 and Ca.sup.2+ in a defined concentration ratio, and methods, including a mechanism and an associated set of protocols, to make the solution without causing autoclave-elicited caramelization and precipitation in the manufacturing process are disclosed. The disclosed composition is particularly useful as a rich energy source for isolated tissue and for peripheral tissues under surgery with concurrent suppression of lactic acid formation and accumulation in the cells. It may be used in ocular surgery and surgeries in general, although other uses, for example, topical application and storage and rinsing of donor tissues prior to transplantation are also contemplated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.