Compounds for the photo decontamination of pathogens in blood
US5654443A · kind A · utility
31Cited by
21References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 31, 1995 |
| Grant date | Aug 5, 1997 |
| Priority date | — |
| Expiry date | May 31, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2/0011
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.