Synthesis of cycloalkyldiarylphosphines
US5654485A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 25, 1996 |
| Grant date | Aug 5, 1997 |
| Priority date | — |
| Expiry date | Mar 25, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/5077
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
By reacting certain partially sterically-hindered chloro-substituted cycloalkanes with sodium and/or potassium diarylphosphides in an ether reaction medium, not only are useful cycloalkyldiarylphosphines produced, but in addition the chloro-substituted cycloalkane does not undergo any appreciable reaction with the coproduced aryl sodium and/or aryl potassium as it is formed. Moreover, the process makes it possible to avoid or at least to greatly reduce interaction with or cleavage of cyclic ether reaction media such as tetrahydrofuran. Thus the process makes possible improvements both in yield and quality of the cycloalkyldiarylphosphite product. A two-stage process conducted in an ether reaction medium is also described. In the first stage the sodium and/or potassium diarylphosphine reactant is produced by reaction between sodium and/or potassium and triarylphosphine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.