Methods of treating TNF-.alpha.-mediated Crohn's disease using chimeric anti-TNF antibodies
US5656272A · kind A · utility
273Cited by
2References
7Claims
0Family size
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Key dates
| Filing date | Feb 4, 1994 |
| Grant date | Aug 12, 1997 |
| Priority date | — |
| Expiry date | Feb 4, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-.alpha. (TNF.alpha.) and are useful in vivo for diagnosis and therapy of a number of TNF.alpha.-mediated pathologies and conditions, including Crohn's disease, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.