Amyloid precursor proteins and method of using same to assess agents which down-regulate formation of .beta.-amyloid peptide
US5656477A · kind A · utility
12Cited by
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14Claims
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Key dates
| Filing date | Sep 20, 1993 |
| Grant date | Aug 12, 1997 |
| Priority date | — |
| Expiry date | Sep 20, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/839
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, about 475 or about 494 amino acid residues in which a portion thereof encodes a .beta.-amyloid protein domain. Also described is a method for screening for a compound which reduces the formation of .beta.-amyloid protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.