Acylated splenopentins, methods for their synthesis and their use

US5656601A · kind A · utility

Assignee

• BERLIN-CHEMIE AG · DE

Inventors

• Klaus Forner · Berlin, DE
• Angelika Ehrlich · Berlin, DE
• Wolfgang Diezel · Berlin, DE
• Rolf Eckert · Berlin, DE
• Elke Euthin · Berlin, DE
• Eberhard Krause · Berlin, DE
• Peter Slonina · Berlin, DE
• Hans-Dieter Volk · Berlin, DE
• Heinrich Repke · Berlin, DE
• Monika Georgi · Berlin, DE
• Martina Leidert · Berlin, DE
• Michael Bienert · Berlin, DE
• Michail Ovcinnikov · Bönen, DE
• Ralph Schmidt · Berlin, DE
• Manfred Schuett · Berlin, DE
• Renate Mentel · Greifswald, DE
• Winfried Breustedt · Berlin, DE

Key dates

• Filing date: Jun 20, 1991
• Grant date: Aug 12, 1997
• Expiry date: Jun 20, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new compounds of acylated splenopentins of Formula I EQU R.sup.1 -arg-lys-(R.sup.2)-glu-val-tyr(R.sup.3)R.sup.4 I wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 are as defined in the specification, methods for their synthesis by acylation of splenopentins, as well as to their use as pharmacologically active peptides which are suitable for normalizing the function of the immunological system in primary and secondary immunological deficiencies.