Arylidene and heteroarylidene oxindole derivatives and process for their preparation
US5656654A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 22, 1994 |
| Grant date | Aug 12, 1997 |
| Priority date | — |
| Expiry date | Jun 22, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Arylidene and heteroarylidene oxindole derivatives of formula (I) ##STR1## wherein, subject to provisos, Y is a bicyclic ring system chosen from naphthalene, tetralin, quinoline and isoquinoline; PA1 R is hydrogen or an oxo (.dbd.O) group when Y is tetralin; or PA1 R is hydrogen when Y is naphthalene, quinoline or isoquinoline; PA1 each of R.sup.1 and R.sup.2 independently is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl; PA1 m is zero, 1 or 2; PA1 n is zero, 1, 2 or 3; PA1 each of R.sup.3 and R.sup.4 independently is hydrogen, halogen, cyano, C.sub.1 -C.sub.6 alkyl, carboxy, nitro or --NR.sup.6 R.sup.7 in which each of R.sup.6 and R.sup.7 independently is hydrogen or C.sub.1 -C.sub.6 alkyl; PA1 R.sup.5 is hydrogen or C.sub.1 -C.sub.6 alkyl; and their pharmaceutically acceptable salts, which are useful as tyrosine kinase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.