Compounds which inhibit complement and/or suppress immune activity
US5656659A · kind A · utility
0Cited by
20References
8Claims
0Family size
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Key dates
| Filing date | Nov 18, 1994 |
| Grant date | Aug 12, 1997 |
| Priority date | — |
| Expiry date | Nov 18, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds which suppress immune responses and/or selectivly inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the phamaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activites, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.