Antagonists of LHRH

US5656727A · kind A · utility

Assignees

• The Administrators of the Tulane Educational Fund · US
• The Board of Regents of the University of Texas System · US

Inventors

• Cyril Y. Bowers · New Orleans, US
• Karl Folkers · Austin, US
• Anna Janecka · Terespol, PL

Key dates

• Filing date: Apr 28, 1995
• Grant date: Aug 12, 1997
• Expiry date: Apr 28, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

LHRH analogs and congeners with high water solubility have been synthesized. These new analogs had 0%-100% antiovulatory activity at a 0.5 .mu.g dosage and 0%-80% at 0.25 .mu.g. The ED.sub.50 for histamine release was 30.5 .mu.g/ml->300 .mu.g/ml.