Preparative capillary electrophoresis with wide-bore capillary
US5658446A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 30, 1996 |
| Grant date | Aug 19, 1997 |
| Priority date | — |
| Expiry date | Jul 30, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/44704
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A wide-bore capillary electrophoresis apparatus for the analysis of analyte ions is provided. The apparatus has a wide-bore capillary that has a restriction zone at one or more ends. The capillary has an inlet end and an outlet end and an opening at each of said ends. The restriction zone is capable of providing fluid communication between the wide bore and the opening at said end. The restriction zone includes a narrow bore extending to the opening and a transition zone providing gradual change of bore diameter from the wide bore to the narrow bore. The apparatus further has a buffer source to supply buffer to the inlet end of the capillary and a power supply for supplying power to drive buffer and analyte ions through the capillary. During CE, electrodes provide electrical communication between the power supply and the inlet end and the outlet end and apply a voltage differential between said ends.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.