Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
US5658583A · kind A · utility
Inventors
Key dates
| Filing date | Jul 28, 1995 |
| Grant date | Aug 19, 1997 |
| Priority date | — |
| Expiry date | Jul 28, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M37/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.