Patent · US Expired

Acylated protein aggregates and their use in suppressing interference in immunoassays

US5658725A · kind A · utility

9Cited by

2References

31Claims

0Family size

Assignee

Boehringer Mannheim GmbH · DE

Inventors

Dittmar Schlieper · Weilheim, DE
Franz Schmid · Bayreuth, DE
Martin Kaufmann · Weilheim, DE

Key dates

Filing date	Aug 21, 1995
Grant date	Aug 19, 1997
Priority date	—
Expiry date	Aug 21, 2015

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S435/975
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Subject matter of the invention are protein-containing interference-reducing agents for immunoassays consisting of protein aggregates that are acylated with --CO--R groups, wherein R is a branched or non-branched C1-C4 alkyl residue which can be substituted with hydroxy, carboxy, SO.sub.3 H or PO.sub.3 H.sub.2 groups. These interference-reducing substances can be used together with a buffer as an interference-reducing agent or together with an immunological binding partner as a binding reagent to reduce non-specific interactions in immunoassays. Another subject matter of the invention is an immunological testing method wherein said interference-reducing substances are used.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.