Method and apparatus for making miniaturized diagnostic arrays
US5658802A · kind A · utility
303Cited by
13References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 7, 1995 |
| Grant date | Aug 19, 1997 |
| Priority date | — |
| Expiry date | Sep 7, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2035/1041
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Arrays of electro-mechanical dispensers are used to form extremely small drops of fluid and locate them precisely on substrate surfaces in miniature arrays. The printed arrays may consist of DNA, immunoassay reagents or the like. A positioning support such as an X-Y table moves the dispensing devices and substrate surfaces relative to each other to locate the drops on the substrates in predetermined patterns. Arrays of probes as dense as one thousand per square centimeter with center-to-center spacing as small as twenty-five micrometers are formed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.