Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
US5658920A · kind A · utility
11Cited by
4References
3Claims
0Family size
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Key dates
| Filing date | May 31, 1995 |
| Grant date | Aug 19, 1997 |
| Priority date | — |
| Expiry date | May 31, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.