Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals

US5658933A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Klaus Weidmann · Kronberg, DE
• Karl-Heinz Baringhaus · Blieskastel, DE
• Georg Tschank · Frankfurt am Main, DE
• Martin Bickel · Frankfurt am Main, DE

Key dates

• Filing date: Oct 31, 1994
• Grant date: Aug 19, 1997
• Expiry date: Oct 31, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06139
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the formula I, ##STR1## to a process for their preparation and to their use as pharmaceuticals. The compounds are employed, in particular, as ester prodrugs of prolyl hydroxylase inhibitors for inhibiting collagen biosynthesis and as fibrosuppressive agents.