Substituted 1H-imidazoles
US5658938A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 8, 1995 |
| Grant date | Aug 19, 1997 |
| Priority date | — |
| Expiry date | Dec 8, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substituted 4-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazoles and 4-(2,3-dihydro-1H-inden-1-yl)-1H-imidazoles, their optical isomers and their racemic mixtures, their salts, methods for preparing them and therapeutic compositions containing them. These compounds have the general formula ##STR1## wherein n=1 or 2, PA1 R.sub.1, R.sub.2, R.sub.3 and R.sub.4 =hydrogen, halogen, hydroxyl C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, PA1 R.sub.5 = hydrogen of C.sub.1 -C.sub.4 alkyl with the proviso that R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, cannot simultaneously be hydrogen when n is equal to 2. These new compounds exhibit anti-ischemic and anti-hypertensive activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.