Oligonucleotide-cyclopropapyrroloindole conjugates as sequence specific hybridization and crosslinking agents for nucleic acids
US5659022A · kind A · utility
20Cited by
9References
25Claims
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Key dates
| Filing date | Jan 5, 1996 |
| Grant date | Aug 19, 1997 |
| Priority date | — |
| Expiry date | Jan 5, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/044
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Covalently linked conjugates of oligonucleotides (ODNs) with a cyclopropapyrroloindole moiety or an analog thereof, selectively and efficiently alkylate and crosslink with nucleic acid sequences that are complementary to the base sequence of the ODN.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.