Process for the preparation of 4-fluorothiophenol

US5659088A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Helmut Fiege · Leverkusen, DE
• Ferdinand Hagedorn · Leverkusen, DE
• Wolfgang Eymann · Neunburg vorm Wald, DE
• Otto Neuner
• Herbert Muller · Bischofswerda, DE

Key dates

• Filing date: Jun 1, 1995
• Grant date: Aug 19, 1997
• Expiry date: Jun 1, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C319/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-Fluorothiophenol is obtained in outstanding purifies and yields if 4-fluorobenzenesulphonyl chloride is reacted with sodium hydrogen sulphite solution to give a solution of sodium 4-fluorobenzenesulphinate, this solution is reduced with sulphur dioxide to give 4,4'-difluorodiphenyl disulphide and finally this is reacted with sodium borohydride in a water-miscible inert organic solvent to give 4-fluorothiophenol (sodium salt). Free 4-fluorothiophenol can be isolated from the sodium salt solution by acidification.