High molecular weight desulphatohirudin
US5661001A · kind A · utility
6Cited by
3References
33Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 29, 1995 |
| Grant date | Aug 26, 1997 |
| Priority date | — |
| Expiry date | Mar 29, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention pertains to the field of thrombin inhibitors and describes the production of modified desulphatohirudins, particularly desulphatohirudins, with the aid of genetic engineering. The present invention is also directed to a method for the denaturation and renaturation of a modified desulphatohirudin to a biologically active thrombin inhibitor and the combination of two or more of desulphatohirudins to form higher molecular weight thrombin inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.