Use of cyclic depsipeptides having 12 ring atoms for combating endoparasites, new cyclic despipeptides having 12 ring atoms, and processes for their preparation

US5663140A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Scherkenbeck · Leverkusen, DE
• Peter Jeschke · Eltville am Rhein, DE
• Andrew Plant · Leverkusen, DE
• Achim Harder · Leverkusen, DE
• Norbert Mencke · Leverkusen, DE

Key dates

• Filing date: Jan 13, 1995
• Grant date: Sep 2, 1997
• Expiry date: Jan 13, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of cyclic depsipeptides having 12 ring atoms of the general formula (I) ##STR1## in which R.sup.1 and R.sup.4 independently of one another represent hydrogen, straight-chain or branched alkyl, cycloalkyl, aralkyl, aryl, heteroaryl or heteroarylalkyl, each of which is optionally substituted, PA1 R.sup.2, R.sup.3, R.sup.5 and R.sup.6 independently of one another represent hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, halogenoalkyl, hydroxyalkyl, alkanoyloxyalkyl, alkoxyalkyl, aryloxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, carboxyalkyl, alkoxycarbonylalkyl, arylalkoxycarbonylalkyl, carbamoylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, guanidinoalkyl which can optionally be substituted by one or two benzyloxycarbonyl radicals or by one, two, three or four alkyl radicals, alkoxycarbonylaminoalkyl, 9-fluorenylmethoxycarbonyl(Fmoc)aminoalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, and optionally substituted aryl, arylalkyl, heteroaryl and heteroarylalkyl, PA1 and their optical isomers and racemates, in medicine and veterinary medicine for combating endoparasites, to new deps…