Hirudin/polyalkylene glycol conjugates and hirudin muteins

US5663141A · kind A · utility

Assignee

• BASF SE

Inventors

• Manfred Kurfuerst · Haßloch, DE
• Klaus Ruebsamen · Neustadt, DE
• Bernhard Schmied · Bischofswerda, DE
• Wolfgang Koerwer · Ludwigshafen, DE
• Juergen Schweden · Deidesheim, DE
• Hans Wolfgang Hoeffken · Ludwigshafen, DE

Key dates

• Filing date: May 29, 1992
• Grant date: Sep 2, 1997
• Expiry date: May 29, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/858
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Hirudin/polyalkylene glycol derivatives of the formula EQU [A--(CH.sub.2).sub.n --[O--(CH.sub.2).sub.nlm --B--].sub.p Hir [sic]I and hirudin muteins and the preparation thereof are described. The compounds are suitable for controlling diseases.