22-en-25-oxa derivatives in the vitamin D series, process for their production, pharmaceutical preparations containing these derivatives as well as their use as pharmaceutical agents

US5663157A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Andreas Steinmeyer · Berlin, DE
• Gerald Kirsch · Berlin, DE
• Gunter Neef · Berlin, DE
• Katica Schwarz · Berlin, DE
• Ruth Thieroff-Ekerdt · Concord, US
• Herbert Wiesinger · Berlin, DE
• Martin Haberey · Berlin, DE

Key dates

• Filing date: Mar 16, 1995
• Grant date: Sep 2, 1997
• Expiry date: Mar 16, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

22-En-24-a-oxa derivatives in the vitamin D series of general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.4, independently of one another, each mean a hydrogen atom, an alkanoyl group with 1 to 9 carbon atoms or an aroyl group, PA1 R.sup.3 mean a hydrogen atom each or a linear or branched alkyl group each with 1 to 4 carbon atoms, a trifluoromethyl group each or a saturated or unsaturated carbocyclic or heterocyclic 3-, 4-, 5- or 6-membered ring formed together with the tertiary carbon atom, and PA1 X means an alkylene radical --(CH.sub.2).sub.n --with n=1, 2 or 3, process for their production and their pharmaceutical use for treating hyperproliferative diseases are disclosed.