Prodrugs of phosphonates

US5663159A · kind A · utility

Assignees

• Institute of Organic Chemistry and Biochemistry of the Academy of · CZ
• REGA STICHTING, V.Z.W. · BE

Inventors

• John E. Starrett, Jr. · Middletown, US
• Muzammil M. Mansuri · Lexington, US
• John C. Martin · Los Alamos, US
• David R. Tortolani · Skillman, US
• Joanne J. Bronson · Madison, US

Key dates

• Filing date: Oct 11, 1994
• Grant date: Sep 2, 1997
• Expiry date: Oct 11, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6584
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.