Certain isoquinoline derivatives having anti-tumor properties

US5663179A · kind A · utility

Assignee

• Laboratoires Glaxo SA · FR

Inventors

• Bernard Dumaitre · Bobigny, FR
• Nerina Dodic · Les Ulis, FR
• Alain Claude-Marie Daugan · Les Ulis, FR
• Pascal Maurice Charles Pianetti · Les Ulis, FR

Key dates

• Filing date: Dec 29, 1994
• Grant date: Sep 2, 1997
• Expiry date: Dec 29, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are described of general formula (I) ##STR1## and salts and solvates thereof, including physiologically acceptable salts and solvates thereof, in which: PA1 Z represents either Het, ##STR2## Het represents an optionally substituted bicyclic or tricyclic ring selected from acricine isoquinolin-1-yl, isoquinolin-3-yl, The novel compounds of formula (I) can sensitize multi-drug resistant cancer cells to chemotherapeutic agents and may be formulated for use in therapy, particularly to improve or increase the efficacy of an anti-tumour drug.