Inhibitors of farnesyl-protein transferase
US5663193A · kind A · utility
2Cited by
17References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 17, 1996 |
| Grant date | Sep 2, 1997 |
| Priority date | — |
| Expiry date | Jul 17, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to non-peptide compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention also relates to the process for the preparation of a compound of this invention by cultivating a culture of Phoma sp. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.