Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation

US5663198A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Bernhard Reul · Herzogenrath, DE
• Walter Petri · Niedernhausen, DE

Key dates

• Filing date: Jul 13, 1994
• Grant date: Sep 2, 1997
• Expiry date: Jul 13, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5015
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation. Drug formulations comprising micronized particles of very sparingly water-soluble drugs which are coated with a natural, physiologically acceptable ampholytic surfactant soluble in water to give a micellar/colloidal solution, and a process for the preparation of these drug formulations, are described. When placed in an appropriate final container and after the addition of a chlorine-free, partially fluorinated propellant gas liquefiable under pressure, these formulations are suitable for inhalation.