Cephalosporin compounds
US5663331A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1995 |
| Grant date | Sep 2, 1997 |
| Priority date | — |
| Expiry date | Jan 23, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to new cephalosporin compounds of the formula (I), particularly 3-position of cephem rings thereof substituted with new thione compounds and pharmaceutically acceptable salts thereof, which have broad antibacterial activities against both Gram-positive and Gram-negative bacteria, and the said compounds can be prepared by reacting the compounds of the formula (II) with the new thione compounds of the formula (III). ##STR1## wherein R.sub.1 is a C.sub.1-4 alkyl(preferably methyl or ethyl), C.sub.3-4 alkenyl(preferably allyl), C.sub.3-4 alkynyl (preferably propargyl) group or --C(R.sup.a) (R.sup.b)CO.sub.2 H(preferably --C(CH.sub.3).sub.2 CO.sub.2 H or --CH.sub.2 CO.sub.2 H), wherein R.sup.1 and R.sup.b, same or different, are a hydrogen atom or a C.sub.1-4 alkyl group; PA1 R.sub.2 is a C.sub.1-4 alkyl(preferably methyl or ethyl), C.sub.3-4 alkenyl(preferably allyl), C.sub.3-4 cycloalkyl(preferably cyclopropyl) group or carboxyalkyl(preferably --CH.sub.2 CO.sub.2 H) group; PA1 R.sub.3 is a 5- or 6-membered heterocyclic compound-containing 1 or 2 nitrogen atom(s) (preferably piperazine, alkylpiperazine-substituted with C.sub.1-4 alkyl at N-- or 2-position …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.