Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
US5663344A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 22, 1994 |
| Grant date | Sep 2, 1997 |
| Priority date | — |
| Expiry date | Jul 22, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D221/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a method for the synthesis of certain bridged fused ring pyridines. Such bridged fused ring pyridines can be converted to huperzine A and analogs of huperzine A. The present invention also covers such bridged fused ring pyridines, compounds utilized for the preparation of the bridged fused ring pyridines and analogs of huperzine A. The compounds are capable of inhibiting cholinesterase enzymes and, therefore, are useful as pharmaceutical agents for treatment of disorders involving cholinesterase enzymes. Examples of such disorders include myasthenia gravis, Alzheimer's dementia and the improvement of senile memory loss.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.