Process for preparing antihistamine tannates

US5663415A · kind A · utility

Assignee

• Jame Fine Chemicals, Inc. · US

Inventors

• Vilas M. Chopdekar · Edison, US
• James R. Schleck · Somerville, US
• Vernon A. Brown · Maplewood, US
• Cheng Guo · Beijing, CN

Key dates

• Filing date: Jun 28, 1996
• Grant date: Sep 2, 1997
• Expiry date: Jun 28, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C209/82
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing pure antihistamine tannate compositions. The antihistamine in the form of its free base is contacted with tannic acid in the presence of water for a period of time of about 5 minutes to 4 hours and at a maximum temperature such that not more than about 5 wt. % of the antihistamine tannate will be decomposed. Water is removed from the antihistamine tannate by freeze-drying.