Animal model of the human immune system
US5663481A · kind A · utility
27Cited by
2References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 6, 1993 |
| Grant date | Sep 2, 1997 |
| Priority date | — |
| Expiry date | Aug 6, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a non-human chimeric mammal having characteristics of a functional human immune system and having functional human lymphocytes reconstituted in the mammal's lymphopoietic tissue, particularly the spleen. The invention also relates to a method of preparing a non-human chimeric mammal, having characteristics of a functional human immune system, by engraftment of human peripheral blood leukocytes into an immunocompromised mammal. Use of the chimeric mammal as a model of the human immune system is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.