Antibodies recognizing tumor associated antigen CA 55.1
US5665357A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 2, 1994 |
| Grant date | Sep 9, 1997 |
| Priority date | — |
| Expiry date | Dec 2, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antibodies which recognize a tumor related antigen designated CA55.1 such as hybridoma 55.1 deposited as ECACC deposit no. 93081901 in which the complementarity determining regions have the following sequences: PA1 a) heavy chain PA2 CDR1 G Y W I H (SEQ ID NO: 27) PA2 CDR2 E V N P S T G R S D Y N E K F K N (SEQ ID NO: 28) PA2 CDR3 E R A Y G Y D D A M D Y (SEQ ID NO: 29) PA1 b) light chain PA2 CDR1 K S S Q S L L N S R T R K N Y L A (SEQ ID NO: 30) PA2 CDR2 W A S T R T S (SEQ ID NO: 31) PA2 CDR3 K Q S Y T L R T (SEQ ID NO: 32) or a conservative analogue thereof. The peptide ACEHRGSGWC (SEQ ID NO: 26), as displayed on the surface of bacteriophage NCIMB No. 40638, is a mimic of the tumor related antigen CA55.1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.