Method and compositions for lowering blood lipids
US5665359A · kind A · utility
6Cited by
2References
14Claims
0Family size
Inventors
Key dates
| Filing date | Apr 29, 1994 |
| Grant date | Sep 9, 1997 |
| Priority date | — |
| Expiry date | Apr 29, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K36/734
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
It has been discovered that the Chinese fruit known as shanzha, and extracts and purified component derived therefrom, can be administered orally to animals to reduce levels of cholesterol in the blood. The mechanism of action is believed to include the "up-regulation" of LDL receptors on cell surfaces and inhibition of transcription factors for sterol responsive genes. Examples demonstrate the isolation of active components and extracts, potential mechanisms of action in animals and cell culture, and conditions promoting retention of activity during storage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.