Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes
US5665391A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 12, 1995 |
| Grant date | Sep 9, 1997 |
| Priority date | — |
| Expiry date | Oct 12, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/07
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A cultured, full-thickness integument substitute is disclosed which can be implanted in a patient suffering from severe burns, for example; and consists of a three-dimensional matrix membrane with essentially two surfaces because the length and width are substantially greater than the thickness; the membrane has pores in the area of a first surface thereof which are directly connected to but substantially larger on average than those in the area of the opposite surface of the membrane, and those pores have immobilized within them cells and components of the dermal layer of the integument; the membrane has pores in the area of a second surface thereof which are directly connected to but substantially smaller on average than those in the area of the opposite surface of the membrane, and those pores have immobilized within them cells and components of the epidermal layer of the integument; the membrane also has a lateral pore structure in its internal space which interconnects those pores which pass from one surface to the other of the membrane, permitting co-planar flow of a liquid or suspension through the membrane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.