Preparation of peptide containing biodegradable microspheres by melt process
US5665428A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 1995 |
| Grant date | Sep 9, 1997 |
| Priority date | — |
| Expiry date | Oct 25, 2015 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J13/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptide/protein biodegradable drug delivery devices are prepared as microspheres without the use of solvents by a polymer melt process. A melt of thermostable polypeptides and an appropriate low melting block copolymer mixture is prepared and dispersed in an appropriate fluid medium such as air, water or an immiscible organic fluid without using any organic solvent to form microdroplets. The fluid medium is cooled to solidify the microdroplets into microspheres and then collected and purified or further processed as drug delivery devices. These biodegradable microspheres are suitable as implantable or injectable pharmaceutical formulations. Following administration as solid microspheres into the body of a warm blooded animal, the formulations absorb water from the body to form a hydrogel from which the polypeptide is released continuously over an extended period of time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.